Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol

進一步降低低密度脂蛋白膽固醇的功效和安全性

在膽固醇治療試驗者合作組織 (CTTC) 中，在患者低密度脂蛋白膽固醇 (LDL-C) 水準約為 3.4 mmol/L (131.5mg/dL)，每 1 mmol/L (38.7 mg/dL) 主要血管事件減少 22%.

把自已的 LDL-C 控制在 1.68mmol/L ( 63mg/dL) 以下,可以降低心血管疾病的機率。

主要結論

In summary, there is a consistent relative risk reduction in major vascular events per further reduction in LDL-C in patient populations starting as low as a median of 1.68mmol/L ( 63mg/dL) with no offsetting adverse effects.

these data suggest futher lowering of ldl-c thresholds for intiating more intensive therapy, or simply tarter in ldl-c at least as low as approximately 0.5mmol/L or 20mg/dL, would further reduce cardiovascular risk.

在患者族群中，從低至中位數1.68mmol/L (63mg/dL) 的低密度脂蛋白膽固醇(LDL-C) 進一步降低，主要血管事件的相對風險會持續降低，且不會產生抵消性副作用。

研究估計 進一步降低 LDL-C 閾值以開始更強化的治療，或簡單地將 LDL-C 降低至至少約 0.5mmol/L 或 20mg/dL，將進一步降低心血管風險。

In Europe or USA cholesterol and triglyceride levels are expressed in mg/dL whilst in the UK, they are usually expressed in mmol/L.

For Total Cholesterol, HDL cholesterol and LDL cholesterol

• To convert from mmol/L to mg/dL multiply by 38.66976;
• To convert from mg/dL to mmol/L multiply by 0.02586.

JAMA Cardiol. doi:10.1001/jamacardio.2018.2258
Published online August 1, 2018.

Marc S. Sabatine, MD, MPH; Stephen D. Wiviott, MD; KyungAh Im, PhD;
Sabina A. Murphy, MPH; Robert P. Giugliano, MD, SM